Ghira was the High Leader of the White Fang up until choosing to step down in order to become Chieftan of Menagerie. The White Fang's practices shifted to more violent measures afterward. Five years later, he becomes infuriated with the organization when his daughter Blake Belladonna reveals to him that the White Fang was present during the Fall of Beacon, attacking innocent civilians and letting Grimm into the school. After learning of Adam Taurus' plans to overthrow Sienna Khan and attack Haven Academy, Ghira decides to try and rally the people of Menagerie to reclaim the White Fang, defend Haven and restore the White Fang's reputation and practices from when he led it.
When Ghira stepped down from the leadership of the White Fang, Sienna Khan became his successor. While the two are no longer seen interacting in the present day, Ghira nevertheless believed in Sienna fighting for the equality of Faunus despite the differing views of achieving it.
As Corsac and Fennec Albain represent the White Fang in Menagerie, Ghira seemingly cooperated with them until Blake reveals the White Fang's involvement with the Fall of Beacon. After learning of Adam's plans for a coup, Ghira confronts the brothers in "Welcome to Haven" but could not have them arrested due to the lack of evidence. In "Alone Together", Ghira is confronted by the brothers during the White Fang's attack on the Belladonna manor, and later fights them alongside Sun Wukong.
Kali is Ghira's wife. They get along nicely and have a healthy marriage. When the White Fang attacks their home while Ghira and Kali are away from each other, both worry for the other's safety as they fight.
Blake is Ghira's daughter. He expresses deep care and kindness toward Blake after he reunites with her. In "A Much Needed Talk", at first, he and Blake make awkward conversation until she emotionally apologizes for not listening to him and staying with the White Fang. Ghira states that he still loves her no matter what paths she takes and is proud of her of making the right choice.
When Sun tries to impress him and Kali in "Menagerie", Ghira reacts suspiciously toward the young man. Not too long later, he openly expresses his dislike to Sun multiple times.
In "Welcome to Haven", even though he dislikes Sun, he agrees with Sun's dislike of the Albain brothers. However, in "Unforeseen Complications", they start to get along with each other as the monkey faunus shows mutual respect for him. In "A Perfect Storm", Ghira decides to fight alongside Sun against the Albain brothers to see his capabilities.